Some people may not fully stabilize between dose reductions, even when the rate of reduction is slowed.
A dose reduction is recommended in patients with hepatic impairment.
Dose delay and dose reduction can result in care that is less than optimal.
Side effects led to dose reduction in 11 subjects (28%).
Individuals who have liver impairment may require dose reduction of about one half or one third.
A dose reduction of perphenazine or the other drug may be necessary.
Levels exceeding 10 μg/mL should be followed by dose reduction.
But he added, "It is not clear that the dose reduction is good for all patients."
The other patients were managed by dose reduction.
Many patients require a dose reduction of 25-50% when changing to oral ketamine.