The downstream targets that are activated in response to Shh pose another challenge.

Its activation mechanism and downstream targets are still not well characterized.

Rather, they are the downstream targets of the signal/transduction pathways and transcription factors that do represent early responses.

Thus, transcriptional regulators and their downstream targets can be identified simultaneously.

Another transcription factor that may be a downstream target of Ngn3 is Nkx2.2 because it's often coexpressed with it.

The downstream target delivers the snapshot to the next target, as in the push model.

When studying signaling pathways, mutations can further highlight the importance of each component used to activate the downstream target.

Elk1 may be a downstream target of BRCA1 in its growth control pathway.

These downstream targets each contain an Akt recognition sequence.

They help stabilize β catenin, which activates downstream targets.