Breaking the pill would cause too much of the drug to be released at one time.

Do not crush or chew the beads because doing so may cause the drug to be released too quickly, increasing side effects.

The low pH environment triggers a quick release of the micelle polymers, causing a majority of the drug to be released at once, rather than gradually like other drug treatments.

Transdermal delivery (sonophoresis) is enhanced through LFUS, which then further allows the drug to be released.

Breaking the pill may cause the drug to be released too early in the digestive tract.

Crushing or chewing the medicine pellets would cause too much of the drug to be released at one time, which may cause a life-threatening overdose.

Breaking the pill may cause too much of the drug to be released at one time, which could increase side effects including seizures.

An additional factor is how long it takes a drug to be released in the body to exert its pharmacological effect.

Heat may cause more drug to be released into your body, increasing the chance of side effects.