Antimotility drugs other than bismuth preparations can worsen or lengthen the illness because the infectious agent is not expelled from the body as rapidly.

Prescription-free drugs are often poor anxiolytics and often worsen the symptoms over time.

Some drugs may cause or worsen symptoms of stress.

The drug causes hypotension and bradycardia and may worsen asthma.

It has been shown that all anti-inflammatory drugs (like ibuprofen and Cox-2 inhibitors) can worsen blood pressure or cause fluid retention.

Some recreational and prescription drugs may cause or worsen symptoms.

On the other hand, some drugs like diuretic "water pills" can actually trigger or worsen incontinence.

Because alcohol and recreational drugs can worsen the symptoms, these should be avoided.

Interest in phosphodiesterase inhibitors such as sildenafil has been limited by the possibility that these drugs might worsen the headache of mountain sickness.

In fact, the drug might worsen the disease.