Until there is an effective substitute to the things we like, change will not occur.

More than this, they offer to the poor man an effective substitute for the saloon.

For years, doctors and researchers have sought an effective substitute in hopes of eliminating a step in the reconstructive process.

A second assumption was that establishing similarity, as described above, is an effective substitute for the previous safety and efficacy requirements.

But tossing it out without an effective substitute is a problem.

After the famous diamond has been found, however, they become effective substitutes for it.

In object-oriented programming languages that do not support higher-order functions, objects can be an effective substitute.

An espresso spoon, which many restaurants use, is an effective substitute.

Nuclear power is a much more effective substitute for crude oil, in terms of both available production capacity and environmental protection.

Sun icon: Act as effective substitutes for the treasure of the Inca, once it has been found.