However, although v-IL-10 is able to block early-stage disease, it is ineffective in reversing established disease.

Although a handful of human cases had been reported worldwide, babesiosis was not previously known as an established human disease.

However, unlike v-IL-10, IL-4 is able to confer a contralateral therapeutic effect in mice with established disease.

In contrast, the present results demonstrate that local IL-4 delivery was able partially to reverse progression of established disease after local periarticular injection.

Diagnostic tests can also be used to provide prognostic information on people with established disease.

At the moment, gene therapy researchers are aiming their fledging attempts at living patients with established diseases.

Most current trials seeking to treat people with type 1 diabetes do not include those with established disease.

The globulin level may be normal in established disease.

I've never seen such deterioration in anyone under seventy except with established aortic disease.

In 2002, many would consider it unethical to withhold statins from patients with established coronary disease.