"Perhaps because I am Jewish, it gave me a sense of extreme sadness and loss and claustrophobia."

For just a moment, there seemed to be extreme sadness in his face, and then with effort he forced it off.

The only feeling inside, other than the pain, was one of extreme sadness.

A circular swinging of the ponytail, expressing extreme sadness and frustration.

We cherish our friendship and cannot put into words our extreme sadness at his sudden & premature passing.

He talked about his extreme sadness that two agents had died.

She described the mood among workers at the archdiocese as extreme sadness and anger.

These are likely to include extreme sadness and anger.

In the bright morning sunshine the gaunt features had a look of extreme sadness.

Typically in her films, happy and comfortable characters are met by situations of extreme sadness and catastrophe.