As they get older, their frustration and an accurate feeling of rejection cause them to retreat from painful social interaction.

The frustration he caused her was the keynote of every one-sided altercation.

But the frustration for the lack of the expected result caused big problems to the leading coalition.

The frustration of it caused him to lose his mind, and he died at the age of sixty.

Growing frustrations with the restrictions of apartheid, caused him to move to Swaziland where he worked as a teacher.

His frustration with riding the bench finally caused him to change his outlook.

His frustration with Betty's condition and the doctors causes him to assault the doctor and get kicked out of the hospital.

Exhaustion and frustration caused her to miss at least a week of work, she said.

This frustration caused them to gain an interest in the emerging Indonesian nationalist movement.

Unexpressed frustration and anger can also cause other problems, such as physical illness or depression.