Mice containing no functional copies of the gene are not viable.
Mice carrying only one functional copy of igf1r are normal, but exhibit a 15% decrease in body mass.
There is no equivalent offer in the current version (6.5), although a short-lived fully functional copy of the application can be downloaded from the web.
X-inactivation ensures that females, like males, have one functional copy of the X chromosome in each body cell.
Mice without a functional copy of the Mef2c gene die before birth and have abnormalities in the heart and vascular system.
The Internet Archive last stored a functional copy of the website in November 2007, as can be seen here.
The loss of a duplicated gene's functionality usually has little effect on an organism's fitness, since an intact functional copy still exists.
Gene therapy is the genetic engineering of humans by replacing defective human genes with functional copies.
Embryonic stem cells incorporate the altered gene, which replaces the already present functional copy.
The donor cell maintains a functional copy of the plasmid.