It refers to functionally relevant modifications to the genome that do not involve a change in the nucleotide sequence.

Detergents are frequently employed to disrupt cells for the demonstration and isolation of functionally relevant protein complexes and/or to selectively extract certain proteins.

Functionally relevant polymorphisms are reported that cause functional impairment and thus, in general, reduced survival rates, in particular in infections/sepsis with Gram-positive bacteria.

However, what is functionally relevant are differences in composition and "wiring".

Epigenetic alterations refer to functionally relevant modifications to the genome that do not involve a change in the nucleotide sequence.

"Knowing that these brain areas are functionally relevant for tinnitus makes them a primary target for modern therapeutic methods based on brain stimulation," he said.

Thus, epidemiological associations between increased IOP and obesity or diabetes are supported by this work and appear to be functionally relevant.

One possibility is that many of the examples of overlaps, whether functionally relevant or not, are not general to mammals but are lineage-specific in nature.

Lipman [ 13] hypothesized that the existence of functionally relevant overlapping antisense transcripts might explain a subset of these cases.

One of the few areas where functionally relevant information on sequences is available relates to the neoplastic versus non-neoplastic nature of the tissue of origin of EST libraries.