The best way to fix CSS problems with IE6 is to generate random mutations on the style sheet until it looks fixed.
When the cell uses the non-homologous end joining pathway to repair the double-strand break, the inherent inaccuracy of the repair often generates precisely targeted mutations.
Some alterations to the PCR protocol can generate mutations (general or site-directed) of an inserted fragment.
Initially, this was done by generating random mutations in an organism, often with radiation or insertional mutagenesis (ex.
The ability to generate specific mutations in mice may help in identifying those molecules.
Site-directed mutagenesis is used to generate mutations that may produce rationally designed protein that has improved or special properties.
Initially the ability of radiation and chemical mutagens to cause mutation was exploited to generate random mutations, later techniques were developed to introduce specific mutations.
Atomic gardens are a form of mutation breeding where plants are exposed to radioactive sources, typically Cobalt-60, in order to generate useful mutations.
We have not yet generated mutations in BOI1 that would allow us to probe the role of Boi1's interaction specifically with Cdc42.
They generated random mutations in fruit flies using a chemical.