Thus glucose-6-phosphatase mediates the final, key, step in both of the two main processes of glucose production during fasting.

Metformin works by suppressing glucose production by the liver.

One of the biguanide drugs, which cut the liver's glucose production.

Insulin exerts pivotal control of glucose levels through its ability to regulate hepatic glucose production directly or indirectly.

Glucagon also regulates the rate of glucose production through lipolysis.

Metformin is a biguanide that decreases the liver's excess glucose production.

At this stage, hyperglycemia can be reversed by a variety of measures and medications that improve insulin sensitivity or reduce glucose production by the liver.

The regulation of glucose production in the kidney is achieved by action of insulin, catecholamines and other hormones.

This normal reduction in the liver's glucose production may not occur in people with insulin resistance.

Prior to beginning the hyperinsulinemic period, a 3h tracer infusion enables one to determine the basal rate of glucose production.