The expanding role of the market in health care is one of the gravest challenges to a sustainable medicine.

The Commonwealth was unprepared to deal with grave challenges that materialized in the middle of the century.

The nomenklatura system is also facing grave challenges due to the development of the market economy and private entrepreneurship in China.

But it is at home where the party he has shaped will face its gravest challenges.

The protests were seen as the gravest challenge faced by the Ravalomanana government since he came to office in 2002.

The leadership of my planet is experiencing grave challenge.

Our holy mother faces her gravest challenge in half a millenium.

But the world's most failed state still faces grave challenges.

But we will be utterly committed to working with you to address the grave economic challenges which we all face.

In a world short of fresh water, one of the gravest challenges facing governments is that needs and supplies are often far apart.