Genis returns to the present, suffering great anguish from his choice.

"It is a matter of great anguish," he said.

And she crossed her heart in great anguish.

I cannot imagine a greater anguish for a head of state who has himself known the experience of combat than sending young men to war.

Hunting had been the cause of great anguish for her in the past.

immediate enough to know that if you don't, azadeh will have greater anguish.

You must understand - it's a time of great anguish and emptiness.

This caused and is still causing great anguish throughout Poland.

"This is terrible," he cried in great anguish of spirit.

As you presently are, this does not seem a consideration, but it has the potential to cause great anguish later.