Wayne's failure to serve in the conflict was a source of great guilt for him.

That' s our stupidity,'he said sadly as if unburdening himself of a great guilt.

A saint, who hast as much of human failing as ever I did have, and great guilt!

I feel great guilt at this doubt, that I know should not exist.

"I've had a certain feeling, Doctor, which has created great guilt and angst and confusion in my mind."

Even though there were too many people on the deck prior to his arrival, Hurley feels great guilt.

This becomes his one failure and a source of great guilt.

She brought him to a phenomenal climax, enhanced by its great guilt.

On this level she felt great guilt.

Out of guilt-sense we turned reparation into a monstrously greater guilt.