He was staring at his mass detector readings in great irritation.

Gibbs was proving to be a source of great irritation to him.

His tiny claws scratched with great irritation at the topmost part of his arms.

To his great irritation, Worf had no idea what happened.

Our American victories in the field and at sea have caused them great irritation.

Most people were, to her great irritation.

Lopwitz hung up and looked at Sherman with great irritation.

An even greater irritation is the way the audio freezes every few minutes.

"It's always a great irritation to me to be asked about money," the composer said from London during a recent telephone interview.

This was a source of great irritation to all concerned.