At times I thought my guilt and grief would drive me mad.

Shock and grief drove her to sound that well of oblivion; but as Taen extended her senses, evil moved at its heart.

Didion describes how grief for her husband and her daughter drove her crazy.

If she did that, he knew that his grief, and his guilt, would surely drive him mad.

Some awful grief had driven her to it.

Maybe grief has driven her insane.

The grief drove him to compose poetry filled with anguish.

Our grief drove us apart to some extent.

That grief drove him over the edge, robbing him of the morals and beliefs she knew he had once ascribed to.

The meaning, one guessed, was that Orfeo's grief had driven him to play a game of Simon Says, all by himself.