At times I thought my guilt and grief would drive me mad.

The guilt and stress of the last few weeks would have driven anyone insane.

His rage, guilt, and remorse drove him on like a madman.

This action haunts him, and his guilt eventually drives him insane.

Your best guess is that he's the one who did the Wrigley Building murder, and the guilt drove him crazy.

The guilt would drive a fine man like Doc Spiver to shoot himself.

And that memory, or some perceived guilt, drove Sarsa's rebellion?

If He is just, your guilt will slowly drive you mad.

Daddy always said the guilt drove him out of his mind.

But the guilt and the pain and the sheer stark need drove her on.