The removal of the color filter array also means that no incoming light is filtered, making the sensor more light sensitive, which explains the high native ISO of 320.

When a strobe can't be used in dangerous areas because it would diminish spontaneity or jeopardize his own safety, he pushes T-Max to as high as 12,000 ISO.

At the same time, the digital noise that comes with high ISO today will diminish.

This requires either a slow shutter speed, brilliant lighting, or a high ISO.

Available scene modes include portrait, night portrait, landscape, night landscape, closeup, sports, snow, beach, text/document, backlight, museum/manner, fireworks, high ISO, children, flower, self-portrait, sunset and candlelight.

But shooting at higher ISO has drawbacks.

A film with a particular ISO rating can be push-processed, or "pushed", to behave like a film with a higher ISO, by developing for a longer amount of time or at a higher temperature than usual.

A higher ISO could capture action better in low-light conditions.

Selectable high ISO noise reduction in camera Off/Low/Normal/High.

As others have mentioned, high iso and dynamic range performance are much more important than more MPixels.