However, two hours of use did lead to significant melatonin suppression.

An hour led to a day, a week, the ache for a lifetime.

The grueling hours led some to quit, they said.

Later she wondered if the hours alone with the sick man had not led to her decision to marry.

In terms of lifestyle, working odd hours leads to some obvious problems.

Those three hours led to the signing of the player who changed a program the way few can.

Now he returned to the hatch, frustrated that several hours of work had led nowhere.

He is a workaholic who loves his job, but the long hours and low pay are leading to discontent.

At 10, the final hour leading into the news, many more men take over the dial, so adult drama is the staple.

Traders said it was too early to tell whether the longer hours would lead to more business.