He often travelled to meet great scientists, which made him an important mediator.

He was an important mediator during the height of the Investiture Controversy.

IL-6 is one of the most important mediators of fever and of the acute phase response.

However, the story is not set in isolation; indeed, the characters themselves are important mediators between issues of local or wider scope.

Innate cells are also important mediators in the activation of the adaptive immune system.

Recent evidence suggests that mast cells may be important mediators of T-dependent peripheral tolerance.

Authors point out that adults are still important mediators of adolescents' activity during this period, only less directly than when children were younger (Karpov 2005).

Thus p27 Kip1is an important mediator of cell growth inhibition in response to rapamycin.

This suggests that dopamine may be an important mediator of risky behavior.

Locally and seasonally occurring at several 100 individuals m-2, they are important mediators for particulate organic matter from the sea ice to the water column.