However, it is also true that Collins' work has an important historical significance.

It was found that these conformational changes may have a very important physiological significance.

I think the school has an important potential significance.

The leg had potentially important evidentiary significance in the case.

Blue in Judaism has thus had an important significance throughout the history of Jewish culture up to the present.

The last word that the mysterious hand had written was filled with important significance.

The Onega basin area has an important historical and cultural significance.

Anyway the lawsuit had a very important social significance, and from then on women's inheritance problem followed her practice.

His fall had important significance to the fate of the monarchy in France before 1789.

It wasn't a long number, it was two digits, had some very important significance.