These could include having to work in extremes of temperature.
He punished his children in varying extremes on a daily basis.
Both parents were illiterate and the family lived in extremes of poverty common at the time.
In extremes, not to be alone is the greatest aid to survival.
"In extremes, I may have done some good magic," he admitted.
The most obvious is his belief in extremes of volume.
"I want to know what people will do in extremes," he goes on.
This courtroom (so he had read) was a study in extremes.
It held a small device, to be used only in extremes.
Here the basic elements of the earth exist in paradoxical extremes.