Mother took a lot of interest in her patients, whether they could pay or not.
They've almost certainly come across the problem in other patients.
In some patients they may go away after continued use.
By 2008 it had been used in over 350,000 patients.
Over a two year period this approach was used in 40 such patients.
There has been at least one death in such patients.
It is also the most common cause of death in such patients.
The man was interested in his patients, but they never kept him up at night.
The drug should not be used in patients with heart disease, it said.
In patients with more than one medical condition the risk was higher.