He was named after Túpac Amaru, a Peruvian revolutionary who led an indigenous uprising against Spain and was subsequently executed.

In 1537, there were widespread indigenous uprisings in Honduras, and the Cares were one group that revolted against Spanish rule.

A system of forced labor was not only tolerated but encouraged, and it is no surprise that by the 18th century there were several indigenous uprisings against the Spanish ruling classes.

This finally boiled over into the 1780 indigenous uprising, led by Túpac Amaru II.

The church was initially established in a native settlement, but then was destroyed by fire, probably during an indigenous uprising.

Native Hondurans had long resisted Spanish invasion and enslavement, and in 1537, a young Lenca chief named Lempira led an indigenous uprising against the Spanish.

Further indigenous uprisings near Gracias a Dios, Comayagua, and Olancho occurred in 1537-38.

On 30 July 1847 it exploded in Yucatán the indigenous uprising known as the war of castes.

In 1848, when Yucatan fell victim to a brutal indigenous uprising, fearful criolos considered annexation to either the United States or Spain to save themselves.

But unpopular economic policies, heavy taxes and a cholera epidemic led to an indigenous uprising that brought its leader, a conservative ladino pig farmer, Rafael Carrera, to power.