H2- typing of the global wild mice population revealed it to be fragmented into a large number of small subpopulations (demes), which differed in the presence and frequencies of alleles at the individual loci.

The term loci theologici gradually came to denote the content, and thus the chief passages of the Bible as included in the individual loci.

However, with specific regards to epigenetically active transgene loci, it is often not transparent whether their silencing behavior was stable over successive generations, nor when and how individual loci acquired their epigenetic activity.

The most pressing need in investigating the genetic contribution to Crohn's disease is the collection of multiply affected families for RFLP linkage studies, to identify individual loci that contribute to liability.

The first of these, complex trait analysis, is a comparatively new genetic method that makes it possible to map individual loci that underlie polygenic traits [ 22, 23].

If genes or operons have been eliminated individually in separate events, their loss may be governed by the functional roles and independent fitness effects of individual loci.

Rather than seeking to identify individual loci significantly associated with a trait, genomics uses all marker data as predictors of performance and consequently delivers more accurate predictions.

These 'large steps' imply that genome reduction involved some random chance (due to the location of genes in the ancestral chromosome) and selection acting on the combined fitness of large sets of genes, rather than the fitness of individual loci.

It was also apparent that the individual loci were mutating at different rates.

This classification is not only simpler but also preferable in evolutionary genetics, since the absolute sign of epistasis matters more than relationship between sign of epistasis and sign of individual loci's effect on phenotype.