There is indeed direct evidence that mechanical stress can generate intracellular signals that regulate gene expression.

Testosterone binds to and activates androgen receptor, affecting intracellular signals and modifying the expression of numerous genes.

It was clear, however, that gustducin acted like transducin, and transduced intracellular signals.

The activity of transcription factors is further modulated by intracellular signals causing protein post-translational modification including phosphorylated, acetylated, or glycosylated.

Environmental stimuli or endocrine signals may cause modification of regulatory proteins eliciting cascades of intracellular signals, which result in regulation of gene expression.

The control of alternative RNA splicing is performed by complex network of signaling molecules that respond to a wide range of intracellular and extracellular signals.

This results in halting of the cascade of intracellular signals dependent on this receptor.

Endocytic PRRs promote the attachment, engulfment and destruction of microorganisms by phagocytes, without relaying an intracellular signal.

Thus, intracellular signals must coordinate the synthesis of rRNA with that of other components of protein translation.

Dr. Schreiber also found a third drug, rapamycin, that works by a similar mechanism to alter intracellular signals.