Bortezomib is given in frequent intravenous doses and can cause significant neuropathic toxicities.
After an intravenous dose the analgesia sets in after 3-5 minutes.
To date, 0.02% of patients suffered fatal reactions following the first intravenous dose.
Following an intravenous dose, 45% is excreted as unchanged parent drug and 7% amphetamine.
The oral and intravenous doses of a drug such as paracetamol will differ for the same reason.
After a 4 mg intravenous dose, the elimination half-life is approximately 24 hours.
The old treatment also required a month of intravenous doses to be effective, whereas the new drug requires only two weeks of treatment.
Medical treatment in 1880, included the use of intravenous doses of a drug called pilocarpin.
In the study, 10 people who had sciatica caused by a herniated disc were given an intravenous dose of Remicade over two hours.
Experiments with monkeys proved that daily intravenous doses of tartaric acid were an effective treatment.