The biggest mystery is the exact nature of the infection that seemed to start the prolonged, irreversible course of the bleeding disorder, D.I.C.

"A commitment assumed by the contras," declared a lead editorial in the official Sandinista newspaper, Barricada, "puts the process of concluding the war on an irreversible course."

After their talks, Mr. Bush praised Mr. de Klerk as a courageous leader who had put his country on an "irreversible" course toward dismantling apartheid.

It is, needless to say, a horrible experience as the disease creeps steadily on its progressive and irreversible course.

She remembered a story about an Italian river that, once crossed, committed one to an irreversible course.

The shift toward more consumption is most striking in the Germanys, which appear to be on an irreversible course toward reunification.

A3 South Africa's political system is on an irreversible course toward nonracial democracy, President de Klerk was reported to have told Secretary Baker.

I have mankind's best future in mind and have set our irreversible course.

Such killers, Mr. Ressler said, are usually devoid of hope and have set upon an irreversible course of self-destruction.

He deserves to be commended for his contribution to Korea's democratization, which is on an irreversible course.