Chronic kidney disease (CKD) can develop slowly and show few initial symptoms, be the long term result of irreversible acute disease or be part of a disease progression.

Degenerative myelopathy is an irreversible, progressive disease that cannot be cured.

For example, persons suffering from progressive, irreversible diseases characterised by degeneration of the brain cells such as Alzheimer's disease would require complete external care.

Unlike those chronic, irreversible mental diseases, the confused states are usually transient and may clear up in a matter of hours or days.

There is no currently known cure for spinocerebellar ataxia, which is considered to be a progressive and irreversible disease, although not all types cause equally severe disability.

Chronic obstructive pulmonary disease (COPD) is a group of long-term, irreversible diseases that make it difficult to breathe because air does not flow easily out of the lungs.

Air pollution is a major contributor to C.O.P.D., an irreversible disease that progressively destroys the lungs.

Thus, he or she can speak for you if you become temporarily incapacitated-after an accident, for example-as well as if you become incapacitated because of irreversible disease or injury.

The consequences of this irreversible degenerative disease are above all human.

Alzheimer's is a progressive, irreversible disease characterized by the degeneration of brain cells, leading to loss of memory and altered behavior.