Aspirin is non-selective and irreversibly inhibits both forms.

Feverfew extracts and parthenolide irreversibly inhibit vascular responses of the rabbit aorta.

These small molecules irreversibly inhibited BTK by using a Michael acceptor for binding to the target cysteine.

Furanocoumarins irreversibly inhibit a cytochrome P450 metabolizing enzyme called CYP3A4, as stated above.

In this model, hydrazine sulfate is therefore thought to act by irreversibly inhibiting the enzyme phosphoenolpyruvate carboxykinase.

Margatoxin irreversibly inhibits the proliferation of human T-cells in a concentration of 20 μM.

Aspirin irreversibly inhibits platelet cyclooxygenase 1 preventing the formation of prostaglandin H2, and therefore thromboxane A2.

The organophosphate insecticides such as malathion, parathion, and chlorpyrifos irreversibly inhibit acetylcholinesterase.

E-64 is an epoxide which can irreversibly inhibit a wide range of cysteine peptidases.

Aspirin irreversibly inhibits COX-1 and modifies the enzymatic activity of COX-2.