Not 10 minutes later, the couple's lives were irrevocably altered.

Those who see it will find themselves irrevocably altered by the experience.

Except for a feeling that her perception of things was about to be irrevocably altered.

Human history, whatever it turns out to be, has now been profoundly and irrevocably altered.

What if his presence here had irrevocably altered the timeline?

If it is approved, opponents say, the landscape will be irrevocably altered.

The sense of self of these women has been irrevocably altered.

By the time it came out, in any case, all their lives had been irrevocably altered by the progress of world events.

He had done so, then fled the crusaders, his life irrevocably altered by that experience.

Do we wish to alter irrevocably our understanding of the role of the doctor?