Reperfusion injury is classified as the damage that ensues after restoration of blood supply to ischemic tissue.

This can lead to the instauration of automaticity in ischemic tissue.

Restoration of blood supply to ischemic tissues can cause additional damage known as reperfusion injury that can be more damaging than the initial ischemia.

Achieving vessel stability The induction of new vessels to supply ischemic tissues is the primary goal of angiogenic therapy.

Negative pressure wound therapy (NPWT) is a treatment that improves ischemic tissues and removes wound fluid used by bacteria.

These processes are the same for any type of ischemic tissue and are referred to collectively as the ischemic cascade.

The mitogenic and morphogenic properties of HGF induce recruited stem cells to take on cardiomyocyte phenotypes, potentially helping in the healing of ischemic tissue.

One widely accepted definition for penumbra describes the area as "ischemic tissue potentially destined for infarction but not yet irreversibly injured and the target of acute therapies."

It is designed to express isoforms of hepatocyte growth factor (HGF) for the formation of new blood vessels when injected around ischemic tissue.

This blockage of blood vessels by leukocytes may be responsible for the "no reflow phenomenon," in which ischemic tissue is never fully reperfused.