Peroxiredoxin 1 knockout mice have a 15% reduction in lifespan.

Genetically modified mice are often used to study cellular and tissue-specific responses to disease (cf knockout mouse).

Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice.

Homozygous knockout mice also have neural tube defects followed by craniofacial and body wall abnormalities.

These myostatin "knockout" mice have approximately twice as much muscle as normal mice.

The technique for creating "knockout" mice, strains missing a single gene, is invaluable in biomedical research, but it takes months to generate each strain.

Experiments into the function of the receptor subtypes involve mostly genetic knockout mice.

However desmin knockout mice develop normally and only experience defects later in life.

Genetic knockout mice lacking the gene for orexin were also reported to exhibit narcolepsy.

The Thy-1 knockout (KO) mice are viable and appear grossly normal.