From what she knew of the Akerian nature, Janeway felt certain it was coming back to continue the fight.
Something is known of the physical nature of the change in the synapse.
Little is currently known of the nature of super-Earths.
What do you know of the nature of God, David?
He knew now a little of the nature of that project.
Little is known of the nature of his occupations during the next two years ( went to Tibet?)
Nothing is known of the nature of their responses.
We can never know of the true nature of the thing, but only how it appears to us in context.
Of course nobody does this, even if they know of the harmful nature of the substance.
We have known of the nature of Solarians for many centuries.