The reader senses that one large cause of events is missing.

Reform, like any other large cause, is never something that gets achieved overnight.

Indeed, the largest cause of personal bankruptcies in the country is health care costs.

Smoking is the largest single cause of chronic disease and premature death in our society.

Infectious disease is a large cause of pain and death.

They are just God's temporary instrument in service of a larger cause.

He taught his pupils for 25 years instead of a large and immortal religious cause.

It's the third largest cause of death among men.

As others have said, stress is potentially the largest cause of time off work.

Whatever your position on the matter, this is the largest cause of racism.