It lies along former U.S. Route 66 (Route 96) twenty-one miles east of Carthage.

It lies along U.S. Route 77 north of the city of Giddings, the county seat of Lee County.

Bernardston lies along the path of Interstate 91 and U.S. Route 5, both of which pass from Greenfield through town towards the Vermont state line.

It lies along U.S. Route 6 east of the city of Marengo, the county seat of Iowa County.

Benton lies along U.S. Route 6, outside of Bishop, on the way to remote areas of Nevada.

It lies along U.S. Route 75 north of the city of Independence, the county seat of Montgomery County.

It lies along former U.S. Route 66 (now a county road) about six miles (10 km) west of Halltown.

It lies along U.S. Route 151 north of the city of Anamosa, the county seat of Jones County.

It lies along U.S. Route 30 west of the city of Fremont, the county seat of Dodge County.

It lies along historic U.S. Route 66, now an outer road of Interstate 44.