Most of these patients were using the only effective drug then available, bromide, which had terrible side effects and limited efficacy.
However, the limited efficacy and potentially life-threatening side-effects of currently available thrombolytic agents remain a difficulty.
Animal traps are considered as inhumane and inefficient on a large scale, for example, due to the limited efficacy of baits.
The use of therapeutic vaccination is an obvious intervention that still needs to be tested, despite limited efficacy results in treated chronic infection.
Something else with limited efficacy in broiling dry heat is a mobile phone, and here we reach a flaw in the business strategy.
Cholera can be prevented with limited efficacy by two oral vaccines, but access to clean drinking water provides a guarantee of prevention.
Beyond limited economic efficacy, casinos have faced criticism on cultural grounds.
The existing BCG vaccine is cheap, safe, widely used but of limited efficacy.
Treatment was of limited efficacy in this case although tolazoline is reportedly an effective treatment where available.
Allied to this are views about the limited efficacy of law.