Each of these medicines may have local and systemic side effects.

The local spatial effects are becoming more intense by the hour.

Many nutritional problems stem from local effects of the tumor.

Strictly a local effect, but in the process getting from here to there becomes a relatively simple matter instead of an intensely difficult one.

Another local environmental effect, can include the presence of plants or animals that are aided by the coal fire.

This study also reviewed evidence on the local effects of building at higher densities.

Meanwhile many studies of potential local effects of rising sea level are under way.

Now there may be smaller ones in these waters that would produce a local effect.

Their venom is believed to be mild, with local effects only.

"But they'll never be big enough to have more than a local effect."