The neighbouring coal industry and textile industry were to a large extent lost starting from the 1960s.
The Patriots lost starting tackle Bruce Armstrong, arguably their best offensive lineman, who is out for the season with a knee injury.
The Buffaloes lost starting quarterback Darian Hagan to an ankle injury in the first quarter.
The previous meeting saw Michigan lose starting quarterback Denard Robinson to injury in the first half and it eventually lost the game 23-9.
The Eagles dropped to 3-2 and lost starting quarterback Rodney Peete for the season, while the Cowboys moved to 2-3.
The Spurs lost starting forward Sean Elliott, who broke his nose in the second period and did not play the rest of the game.
At one point the club was 9-12 after a three game winning streak only to lose starting import point guard for the season.
There, they lost starting quarterback Rex Grossman from a season-ending knee injury.
Handley's moves upset players who lost starting jobs.
The Panthers return four starters, losing only starting forward sophomore Pepper Wilson.