He observes that the Dutch 18-year-olds of 1962 had a major nutritional handicap.

You can drive across Singapore in 30 minutes, so staying outside the center is no major handicap.

For some patients this is a major handicap to the device.

Victories in major handicaps all over the country this year him the top weight of 124 pounds tonight.

Despite their growing acceptance, graphic novels still face major handicaps.

And when characters actually start dying, his naïveté turns into a major handicap.

And if prime location is everything, his venture had a major handicap.

Another major handicap for the Italians was the shortage of fuel.

Their proliferation is today a major handicap for agricultural development.

They were well received but the special ammunition problem was a major handicap.