In some waterfront areas, driftwood is a major nuisance.

They are also a major nuisance at some airports, where their size makes them a significant birdstrike hazard.

Volvo surveys had found (among many other things) that women drivers considered caps to be a major nuisance.

Regularly switching back to a laptop or standard model would be a major nuisance.

And as a private citizen, believe me, you are looked on as a major nuisance.

I tripped over it constantly and it became a major nuisance.

Any debris in the plaster can become a major nuisance.

For the rest of the family, they're a major nuisance - horror stories that ruin every celebration.

The wind coming in off the sea kept the temperature down and prevented insects from becoming a major nuisance.

Minor family, major nuisance, but also a born bootlicker, and those could be useful.