Since that time, the route has not experienced any changes of major significance.

I think Europe 1992 is clearly a factor of major significance in these students' thinking.

No changes of major significance have taken place to the highway throughout its history.

No other changes of major significance have taken place to the highway since then.

The debate on this issue is likely to be one of major political and philosophical significance.

It was opened in 2010 and has major regional significance.

No changes of major significance have taken place to the route since its debut.

Events of major significance can last for a few seconds only.

It is now an issue of major global significance which needs to be put higher up the international agenda.

He also said the project had "major financial significance for the city."