Often the first attacks are triggered by physical illnesses, major stress, or certain medications.

In most cases, the disorder is triggered by a major stress or traumatic event.

The surgery is a major stress on the patient, particularly in the elderly.

For her, the stock market is major stress.

Any kind of major stress like that instantly brings on a flare-up.

This type of attitude change based on emotions can be seen vividly in serial killers who are faced with major stress.

"Try to quit at a time when you can avoid major stress for at least a week or two," says Arvon.

On the other hand, the rigidity of contracts creates a major stress for the people involved, primarily, employees.

It's a major stress for the heart.

There is also a diet for the dog subjected to major stress.