Trading in human lives had to be the most despicable crime on earth.

What he tried to do last night was the most despicable thing I have ever seen.

"This was the most despicable thing that has happened in my 13 years on the town board."

Now I find myself facing it in its most despicable form.

"Sometimes, during the most despicable events in history, there are moments that show you the potential of the human race," he said.

"I find you to be the most despicable kind of man."

It was the most despicable day of my life.

She's got to think I'm the most despicable thing on earth.

One of the most despicable has just come to light.

Was it possible for the most despicable of creatures to change his nature?