It is the most unnatural thing in the world for parents to bury their children.

It seemed to her most unnatural that he should not have come.

"Don't you think acting is the most unnatural thing in the world?"

The heat drained both strength and will alike; it seemed a most unnatural thing.

We then did the most unnatural thing in the world.

In fact, he had actually seemed happy, a most unnatural state of affairs for him.

It struck me as being most unnatural, even though father and son had never really been close.

Discharging the medical staff, however, was a most unnatural thing.

It was a most unnatural act to put a plastic bag over one's head.

Often, successfully treating disease is, indeed, the most unnatural act in the world - and that can be a very good thing.