A two-year experimental mouse study has shown it "probably" causes an increase in liver tumours.
A mouse study shows that it does not increase the probability of promoting skin cancer.
These same low levels have been associated with primary hypersomnia in general in mouse studies.
The journal developed standards for the publication of mouse mutant studies, which are gradually being accepted more widely in the field.
The mouse studies are "remarkable and wonderful," he said, and "very compelling."
He is one of the scientists who did the mouse studies.
However, the requirement for furin cleavage in this process remains controversial based on mouse studies.
Dr. Karpati and his colleagues performed one of the mouse studies.
But, he said, "we need to be cautious since it may not be straightforward moving these mouse studies into humans."
Dogs can also provide a valuable supplement to information from mouse studies.