A mutation in this region may alter these sequences and, thus, change the way the transcription factors bind to the protein.
In other cases these mutations can change what the gene does or even let it do its job a little better than before.
The mutation slightly changed the shape of the spike, making the virus more transmissible.
Some mutations alter a gene's DNA base sequence but do not change the function of the protein made by the gene.
Surprisingly, mutation of the Tyr199 does not eliminate enzyme activity but instead changes the product to 3-trans-enoyl-CoA.
These mutations change flavour, alcohol content, and overall effect consistency of the fineshed product.
Genetic mutations change the way our cells behave.
When the mutations simply change a single amino acid in norrin, the effects are less widespread and severe.
The mutation changes a domain in the channel so it is no longer degraded correctly by the ubiquitin proteasome system.
Probably they would be safe from every predator microbe and virus; mutation might eventually change that, but modern biomedicine should handily cope.