Generally, UEP is an allele for which all copies derive from a single mutational event.

The first mutational event can be inherited (germline or constitutional) and would then be present in all cells in the body.

These factors cause the frequency ( r / N ) to vary greatly, even if the number of mutational events ( m ) is the same.

Whether these three foci have a common origin or arise from different mutational events is unknown.

Any mutational event that disrupts the superhelical structure of DNA carries with it the potential to compromise the genetic stability of a cell.

Subsequently, antibody/antigen binding is improved via mutational events within the antibody genes to produce a complement with higher affinity and selectivity.

Development of cancer was proposed in 1971 to depend on at least two mutational events.

"Because it's big, it offers substantial opportunities for mutational events to deactivate it," Dr. Collins said.

Providing no mutational event occurs the resulting daughter cells are genetically identical to the original cell.

She said she believed that among the green swordtails, a mutational event resulted in a male being endowed with a tiny sword.