And there's more: the science of drug discovery is changing in ways that favor small, nimble biotech companies.

"They are combining their technology portfolios to compete with a very nimble company."

In the last 25 years, the rise of more nimble foreign companies revealed what dinosaurs the Detroit companies were.

Microsoft is the incumbent, and their dominance is being challenged by smaller, more nimble companies.

Paradoxically, some experts say quick and nimble small companies may well end up being more powerful than huge corporate titans that fall behind in technology.

"We wanted something that could communicate that we are a more nimble company and no longer part of a big bureaucracy."

"Instead of the daring, nimble companies they once were, they become prisoners of their own success," he said.

The 300C seemed like a promise of a new, more nimble company.

But if the giants are stumbling, more nimble companies have had some good news.

Others see opportunity in smaller, more nimble companies.